Amantadine (1-aminoadamantane, sold as Symmetrel) is an antiviral drug used both as an antiviral and an antiparkinsonic.It was approved by the Food and Drug Administration in October 1966 as a prophylactic agent against Asian influenza and eventually received approval for the treatment of Influenzavirus A[1][2][3][4] in adults. In 1969 the drug was also discovered by accident to help reduce symptoms of Parkinson’s disease and drug-induced extrapyramidal syndromes. It is a derivative of adamantane, like rimantadine, a similar drug.
Side effects
Amantadine has been associated with several central nervous system side effects, including nervousness, anxiety, agitation, insomnia, difficulty in concentrating, and exacerbations of pre-existing seizure disorders and psychiatric symptoms in patients with schizophrenia or Parkinson’s disease. These side effects are likely due to amantadine’s dopaminergic and adrenergic activity, and to a lesser extent, its activity as an anticholinergic.
Mechanism of action
The mechanism of its antiparkinsonic effect is not fully understood, but it appears to be releasing dopamine from the nerve endings of the brain cells, together with stimulation of norepinephrine response. Furthermore, it appears to be a weak NMDA receptor antagonist and an anticholinergic.
Misuse
Recently, amantadine is reported to have been used in China poultry farming in an effort to protect the birds against avian influenza.[8] In western countries and according to international livestock regulations, amantadine is approved only for use in humans. Chickens in China have received an estimated 2.6 billion doses of amantadine.[8] Avian flu (H5N1) strains in China and southeast Asia are resistant to amantadine, but strains circulating elsewhere seem to be sensitive. If amantadine resistant strains of the virus spread, the drug of choice in an avian flu outbreak will likely be restricted to one of the scarcer and costlier oseltamivir or zanamivir, which work by a different mechanism and are less likely to trigger resistance.
Declining effectiveness
Early in the 2005/2006 flu season, the United States’ Center for Disease Control [CDC] found rates of amantadine resistance to be much higher than in previous seasons. Looking at samples from 26 states yielded the following findings:
Towards a transgenic model of Huntington?s
Researchers from the Yerkes National Primate Research Centre in Atlanta report progress towards creating a primate model of Huntington?s disease with rhesus macaques. It?s not a full model of Huntington?s, but it?s major advance. …
ICSC Baby!
Yay, I’m in Vegas this week for the Int Council of Shopping Centers Conference. More to come but lets say its a big freakin conference. Read and post comments | Send to a friend.
ICSC 2008 LarKC paper
LarKC paper to be published in special session of IEEE International Conference on Semantic Computing (ICSC 2008), 4-7 August 2008, Santa Clara, CA, USA.
One Tree Hill Season 6 Spoilers
One Tree Hill Season 6 Spoilers Since its sort of already come out in the promo I guess I can release what I was sworn to secrecy about. 6.02 will be filmed in Vegas. The only thing is I don?t know if its ?Vegas? in Wilmington or …
Jon Lester
The rest of this blog entry belongs to Jon: “Words can’t describe it right now,” Lester said on the field at Fenway Park. “I really didn’t (think about pitching a no-hitter), just tried to focus on throwing one pitch at a time and going …
Jon Lester Threw a No-Hitter
Red Sox lefty Jon Lester’s big accomplishment of the night was preventing the Royals from getting any hits with his nine-strikeout complete game shutout. That’s a no-hitter! I am shocked, to say the least. My jinx didn’t even work! …
Jon Lester’s 2006 Bowman Chrome autograph card is the one to get …
Now’s not the time to be buying a rookie card of Boston Red Sox pitcher Jon Lester — he just finished off a no-hitter against the Kansas City Royals — but if you are willing to dip your toe in those choppy volatile waters, …
Monkeys Genetically Modified to Have Huntington?s Disease
Two surviving rhesus macaque monkeys have been genetically modified to have Huntington?s disease, a devastating human degenerative brain disease, in an effort to gain a deeper understanding of the fatal ailment and uncover clues to …
Towards a transgenic model of Huntington?s
Researchers from the Yerkes National Primate Research Centre in Atlanta report progress towards creating a primate model of Huntington?s disease with rhesus macaques. It?s not a full model of Huntington?s, but it?s major advance. …
Starship Troopers Miniatures
Opposite the north of Ireland during the hour for retribution would be impossible that more than half a dozen times a day in the telephone; starship troopers miniatures knew that children in the track covered by his employers as “flying …
Topic brought up in Starship Troopers
[quote user=”Rob the 103 Wrestler”] Well first off I think I read Starship Troopers far too many times. I totally disagree with alot of the book but I find myself using the philosophy in it as my own beliefs. But anyway I remember one …
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at - Dina - Starship Posts Troopers Dien, Dina Meyer : Denise Amazon.com: Cinematical - the - Amazon.co.uk: -
Bethany Joy Galeotti (born on April 2, 1981) is an American singer-songwriter, musician and actress.
As a teenager she honed her vocal skills by training with the Director of The Brooklyn College of Opera and not only plays both the guitar and piano but writes her own music as well. As a singer, she has released two independent albums, titled Preincarnate (2002) and Come On Home (2005) and is best known for her chart topping duet When the Stars Go Blue and video release of Songs In My Pocket. Deemed a triple-threat, Galeotti now boasts stage credits that include collaborating with Garry Marshall and Carole King on a new musical as well as working with director Arthur Allan Seidelman on a production of “The Outsiders.”
Most recently Bethany has been known for her role as Haley James Scott on One Tree Hill. Before that she did some time in the soap world on Guiding Light. I only half watched her on each show, but she has a nice quality to her that makes her seem like she’d be a sweet girl. Also an added bonus is she has an equally sweet singing voice. Why more people don’t know about it, or her, I have no idea.
As you know Bethany Joy Galeotti performed a new song on the One Tree Hill season finale called “Feel This”. This song is pretty a nice ballad song with a meaning behind it and its really good. Lastly, its a cover of her husband’s band. Bethany Joy Galeotti is an American singer-songwriter, musician and actress.As a teenager she honed her vocal skills by training with the Director of The Brooklyn College of Opera and not only plays both the guitar and piano but writes.
A peek into our search factory
In terms of new products, we made Google Health publicly available. It offers users a safe and secure way to collect, store, and manage their medical records and health information online. How many of us have touched, or even seen, …
Google Health: A Quick Peek
Now that Google Health has finally launched, I took a quick peek at it while Mark was taking notes at today?s Google Factory Tour presentation. It?s been a long time coming, but at first glance it looks like it will be a strong …
Google Health Launches
Google Health is live at https://www.google.com/health/ after a year and a half since Adam Bosworth announced a health product from Google. “Patients need to be able to better coordinate and manage their own health information. …
I Am Failing To Get Excited About Napster?s 6 Million Songs
Napster just announced that they are now selling their entire catalog of 6 million songs for $0.99/each, no DRM. And for some reason I?m having trouble getting excited about it (CNET, however, has enough excitement for both of us, …
Napster now iPhone compatible
Mobile Entertainment: Napster is looking to take on Apple at its own game by finally offering a full-track music download service and making compatible with iPhone and iPod. The company says music downloaded from the service ($0.99 per …
6 million DRM-free MP3s now at Napster
Probably the most exciting piece of digital music news to come out of CES 2008 was that Napster was planning on offering its complete catalog of more than 6 million tracks in the unprotected MP3 format. Today, with the launch of version …
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EVENTS: BOBBY - at BROWN MTV Blog not - Combs the Combs Archive Pearl’s quincy brown, al b. sure, kim porter, sean combs, quincy combs. free hit counter script Some other posts : al b sure kim porter ; al b sure jesse blaze snider …
HIGHWAY PATROLMAN QUINCY BROWN SHOT AFTER ARREST
WIS NEWS Channel 10 in Columbia, South Carolina is reporting that the man who is accused of shooting South Carolina Highway patrolman Quincy Brown is using the defense that because there have been racist epithets and other slurs hurled …
Quincy Brown Featured on MTV?s My Super Sweet 16
Quincy Brown Quincy Brown, Diddy?s step son, appeared on MTV?s ?My Super Sweet 16? on Monday at 10:00PM EST. He is the son of Kim Porter and Al B Sure. Quincy will be recording a single with a top rap artist, judge a dance contest where …
Troy duffy
Troy Duffy : The Boondsock Saints True Story - MoviesOnline Have you ever heard of Troy Duffy? Odds are most of you have not. He is a prodigy. He wrote and directed Boondock Saints his first movie and sure to b? …
Troy Duffy - Again?
Troy Duffy is surely a very brave man. After the sloppy and half-baked, pulp fictionish, Boondock Saints (1999 release), Troy duffy wants to do a sequel. Sorry, Duffy is doing a sequel of the Boondock Saints.
Troy Duffy again!
Troy Duffy is the unfortunate American director, screenwriter and musician who became a known personality in Hollywood after starting and effectively ending his career as both a film maker and musician over a period of, give or take, …
Le Bachelorette
I?m already addicted to The Bachelorette. Truth be told, this is the first Bachelorette season that I?ve watched. But I did watch the season that she (and everyone else) was rejected by the Bachelor ? the season that stunned America. …
Tonight: ‘The Bachelorette’
I’ve been looking forward to “The Bachelorette” ever since I heard that she’d been tapped to be ABC’s newest heartbreaker. Let’s hope she’s not still carrying a torch for slippery, slippery Brad Womack. - Posted by Kate.
The Bachelorette 4: Episode 1 Live Thoughts
If anyone deserves to be ABC’s new Bachelorette, it’s DeAnna Pappas. After getting her heart broken on national television on season 11 of The Bachelor, by Brad Womack, DeAnna emerged a stronger and (surprisingly) happier person. …
I was linked to 7chan, haha
Noticed “furfag” labeled with flames, and found the best thing ever. http://www.7chan.org/fur/ SFW by the way, no furry crap.
7chan accuses Cult of Scientology of attacking Epilepsy forum
From 7chan:. I would just like to discuss this nasty business about a terrible raid on a forum for the poor people who suffer from epilepsy. What happened there was terrible, and we feel deeply sorry for those affected. …
Get 7chan Password
/x/ - Paranormal /zom/ - Zombies It served as a board dedicated to those banned from 4chan or just fed up with 4chan. Now go to 7chan need password, and you can 7chan password from here: http://www.bugmenot.com/view/www.7chan.com.
schrodinger s cat, charles barkley gambling, ?
schrodinger s cat charles barkley gambling james broderick travis looks in the mirror elizabeth kelly winn gossip girl contest google health the bachelorette mary tyler moore julie newmar nypd rant gormagon ted knight nypd contract …
schrodinger s cat
Schrodinger?s cat Schrödinger?s cat is a famous illustration of the principle in quantum theory of superposition , proposed by Erwin Schrödinger in 1935. Schrödinger?s cat serves to demonstrate the apparent conflict between what quantum …
Flavor Of Love 3 winner.
This was the season finale for Flavor of Love 3. The lady Flavor Flav chose was ??. Thing 2. This meant that ?Black?, whose real name was Candace Cabrera, was the runner up. The winner was a complete surprise. …
?Flavor Of Love 3? Winner Thing 2
Latresha aka Thing 2 won the heart of eccentric hip hop hype man Flavor Flava on Monday night?s finale of VH1?s Flavor of Love 3. Latresha, a twenty-six year old healthcare worker from Artesia, California is the identical twin of ousted …
Thing 2 Flavor of Love 3 WINNER!
Thing 2 is Flavor Love 3?s WINNER, not ?Black?. Flavor Flav tonight chose Thing 2 as his ?lady? in the season finale of Flavor of Love 3, Candace Cabrera or ?Black? nabbed runner up. The episode starts with Black and Sinceer as the …
CSI Miami Season Finale
CSI Miami Season Finale Following 21 installments, CSI: Miami concludes its sixth season with an episode that puts Horatio’s life on the line. Joining the main ensemble tonight are Kim Coastes, who reprises his role as Ron Saris, …
CSI Miami Season Finale.
The CSI team discovered that Manny had a secret that he was about to reveal before he died. He was going to tell about some dangerous ammunition that could be released into Miami. The team had to locate the killer and the secret …
CSI Miami Season Finale: Horatio Caine NOT Dead (Video Evidence)
CSI Miami Season Finale: Horatio Caine NOT Dead (Video Evidence) CSI: Miami?s season finale, ?Going Ballistic,? has many viewers wondering if Horatio Caine is dead. It would appear so, but this is Hollywood my friends, and things aren?t …
Deanna Pappas
DeAnna Pappas is having the last laugh about being unceremoniously dumped by Brad Womack in the finale of the ninth season of ABC’s Reality TV show The Bachelor. Monday night, the 26-year-old realtor from Neunan Ga., begins her reign as …
?Bachelorette? DeAnna Pappas? Crop of Men
The latest version of The Bachelorette started tonight on ABC. This season stars DeAnna Pappas as the ?Bachelorette.? Here is a look at the desperate hookers making a fool of themselves for the beautiful DeAnna:. Brian W. …
Bachelorette: DeAnna Pappas
Although I don’t have time to watch TV or follow reality shows, I actually got hooked on Season 11 of “The Bachelor” for one reason: DeAnna Pappas. Here are some YouTube videos of her. She’s a lovely realtor from Georgia who has many …
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Quincy Brown Kim Porter Al B Sure VIDEO
He is the son of Kim Porter and Al B Sure, and step son of Diddy.Quincy Brown was featured tonight in ?My Super Sweet 16? on MTV. During his ?Stunna 16? bday bash, Quincy recorded ?a single with a top rap artist, judge a dance contest …
Homework
0.670 mol O2 b. 1.34 mol H2O 2 a. 6.60 mol Al b. 6.60 mol Fe c. 3.30 mol Al2O3 Practice B pg 307 1. 45.6g Al 2. 44.6g Al2O3 3. 679g Fe2O3 4. 107g Fe April 7-10 ? Homework Handout (from last class) due next class …
Amantadine (1-aminoadamantane, sold as Symmetrel) is an antiviral drug used both as an antiviral and an antiparkinsonic.It was approved by the Food and Drug Administration in October 1966 as a prophylactic agent against Asian influenza and eventually received approval for the treatment of Influenzavirus A[1][2][3][4] in adults. In 1969 the drug was also discovered by accident to help reduce symptoms of Parkinson’s disease and drug-induced extrapyramidal syndromes. It is a derivative of adamantane, like rimantadine, a similar drug.![[Email]](http://www.feedburner.com/fb/feed-styles/images/email.gif){kind=small}